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Systematic name M41181
Brief description Genes up-regulated in blood 3d vs 0d in adults (21-51) after exposure to Influenza A (H1N1) 2009 Monovalent Vaccine (Sanofi Pasteur) , time point 3D , administered i.m.
Full description or abstract The study aimed at identifying biomarkers of immune response elicited by non-adjuvanted-(NAV) and adjuvanted-(AV) H1N1(pdm09) vaccines. The results showed that despite both vaccines elicited similar levels of anti-H1N1 antibodies at day30 after vaccination, higher reactivity was observed in AV at day180. While AV induced early changes in cell-surface molecules on monocytes, CD4+, CD8+ T-cells and B-cells, NAV triggered minor changes, starting later on at day3. Furthermore, AV induced a late and persistent increase in TLR gene expression after day3, except for tlr4, while NAV displayed earlier but transient tlr3/4/7/9 up-regulation. Contrasting with NAV, prominent chemokine gene expression (cxcl8,cxcl9,ccl5) and a broad spectrum up-regulation of plasmatic biomarkers (CXCL8,IL-6,IL-1beta,IL-12,IL-10) was evident in AV, which showed a major involvement of TNF and IL-10. Similarly, AV induced a robust IL-10-modulated proinflammatory storm, with early and persistent involvement of TNF-alpha/IL-12/IFN-gamma axis derived from NK-cells, CD4+ and CD8+ T-cells along with promiscuous production of IL-4/IL-5/IL-13. Conversely, NAV promotes a concise and restricted intracytoplasmic chemokine/cytokine response, essentially mediated by TNF-alpha and IL-4, with late IL-10 production by CD8+ T-cells. Systems biology approach underscored that AV guided the formation of an imbricate network characterized by a progressive increase in the number of neighborhood connections amongst innate and adaptive immunity. In AV, the early cross-talk between innate and adaptive immunity, followed by the triad NK/CD4+/CD8+ T-cells at day3, sponsored a later/robust biomarker network. These findings indicate the relevance of adjuvanted vaccination to orchestrate broad, balanced and multifactorial cellular immune events that lead ultimately to a stronger H1N1 humoral immunity.
Collection C7: Immunologic Signature
      VAX: HIPC Vaccine Response
Source publication Pubmed 28549970   Authors: Giarola-Silva S,Coelho-Dos-Reis JGA,Mourão MM,Campi-Azevedo AC,Nakagaki Silva EE,Luiza-Silva M,Martins MA,Silveira-Cassette ACO,Batista MA,Peruhype-Magalhães V,Antonelli LRDV,Leite Ribeiro JG,Elói-Santos SM,Machado AV,Teixeira-Carvalho A,Martins-Filho OA,Araújo MSS
Exact source Fig 3: Non-adjuvanted
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Organism Homo sapiens
Source platform HUMAN_GENE_SYMBOL
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Version history 7.3: First Introduced.

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