Human Gene Set: GOBP_ERAD_PATHWAY

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For the Mouse gene set with the same name, see GOBP_ERAD_PATHWAY

Standard name GOBP_ERAD_PATHWAY
Systematic name M15534
Brief description The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome. [GOC:bf, GOC:PARL, PMID:20940304, PMID:21969857]
Full description or abstract  
Collection C5: Ontology
      GO: Gene Ontology
            GO:BP: GO Biological Process
Source publication  
Exact source GO:0036503
Related gene sets  
External links http://amigo.geneontology.org/amigo/term/GO:0036503
Filtered by similarity ?
Organism Homo sapiens
Contributed by Gene Ontology (Gene Ontology Consortium)
Source platform Human_NCBI_Gene_ID
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 111 genes
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Show members (show 112 members mapped to 111 genes)
Version history 2022.1.Hs: Updated to GO Release 2022-07-01, NCBI gene2go 2022-07-15.

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