Human Gene Set: GOBP_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY

GSEA and MSigDB Need Your Support

We are preparing a grant proposal to NCI's Information Technology for Cancer Research program for the continued funding of GSEA and MSigDB. Click here to learn how you can help. (show)

For the Mouse gene set with the same name, see GOBP_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY

Standard name GOBP_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY
Systematic name M11317
Brief description The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered. [GOC:mtg_apoptosis, GOC:yaf, PMID:17340152]
Full description or abstract  
Collection C5: Ontology
      GO: Gene Ontology
            GO:BP: GO Biological Process
Source publication  
Exact source GO:0097191
Related gene sets  
External links http://amigo.geneontology.org/amigo/term/GO:0097191
Filtered by similarity ?
Organism Homo sapiens
Contributed by Gene Ontology (Gene Ontology Consortium)
Source platform Human_NCBI_Gene_ID
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 224 genes
Gene families ? Categorize these 224 genes by gene family
Show members (show 224 members mapped to 224 genes)
Version history 2022.1.Hs: Updated to GO Release 2022-07-01, NCBI gene2go 2022-07-15.

See MSigDB license terms here. Please note that certain gene sets have special access terms.