Human Gene Set: GOBP_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING

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For the Mouse gene set with the same name, see GOBP_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING

Standard name GOBP_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING
Systematic name M10984
Brief description The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. [GOC:bf, GOC:jl, PMID:12773372, Reactome:R-HSA-209560]
Full description or abstract  
Collection C5: Ontology
      GO: Gene Ontology
            GO:BP: GO Biological Process
Source publication  
Exact source GO:0007249
Related gene sets  
External links http://amigo.geneontology.org/amigo/term/GO:0007249
Filtered by similarity ? (show 1 similar ontology term(s) from the external resource)
Organism Homo sapiens
Contributed by Gene Ontology (Gene Ontology Consortium)
Source platform Human_NCBI_Gene_ID
Dataset references  
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Compendia expression profiles ? GTEx compendium
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Version history 2022.1.Hs: Updated to GO Release 2022-07-01, NCBI gene2go 2022-07-15.

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