Human Gene Set: GOBP_NECROTIC_CELL_DEATH

GSEA and MSigDB Need Your Support

We are preparing a grant proposal to NCI's Information Technology for Cancer Research program for the continued funding of GSEA and MSigDB. Click here to learn how you can help. (show)

For the Mouse gene set with the same name, see GOBP_NECROTIC_CELL_DEATH

Standard name GOBP_NECROTIC_CELL_DEATH
Systematic name M10910
Brief description A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues. [GOC:mtg_apoptosis, PMID:18846107, PMID:20823910]
Full description or abstract  
Collection C5: Ontology
      GO: Gene Ontology
            GO:BP: GO Biological Process
Source publication  
Exact source GO:0070265
Related gene sets  
External links http://amigo.geneontology.org/amigo/term/GO:0070265
Filtered by similarity ?
Organism Homo sapiens
Contributed by Gene Ontology (Gene Ontology Consortium)
Source platform Human_NCBI_Gene_ID
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 73 genes
Gene families ? Categorize these 73 genes by gene family
Show members (show 73 members mapped to 73 genes)
Version history 2022.1.Hs: Updated to GO Release 2022-07-01, NCBI gene2go 2022-07-15.

See MSigDB license terms here. Please note that certain gene sets have special access terms.