Human Gene Set: GOCC_VCP_NPL4_UFD1_AAA_ATPASE_COMPLEX

For the Mouse gene set with the same name, see GOCC_VCP_NPL4_UFD1_AAA_ATPASE_COMPLEX

Standard name GOCC_VCP_NPL4_UFD1_AAA_ATPASE_COMPLEX
Systematic name M25792
Brief description A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins. In mammals, this complex includes a hexamer of VCP/p97 (a cytosolic ATPase) and trimers of each of its cofactors UFD1L and NPL4 (NPLOC4) (e.g. a 6:3:3 stoichiometry). [PMID:11813000, PMID:16179952]
Full description or abstract  
Collection C5: Ontology
      GO: Gene Ontology
            GO:CC: GO Cellular Component
Source publication  
Exact source GO:0034098
Related gene sets  
External links http://amigo.geneontology.org/amigo/term/GO:0034098
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Source species Homo sapiens
Contributed by Gene Ontology (Gene Ontology Consortium)
Source platform or
identifier namespace		 Human_NCBI_Gene_ID
Dataset references  
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Version history 2026.1.Hs: Updated to GO Release 2025-10-10.


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