Human Gene Set: GOCC_WEIBEL_PALADE_BODY

For the Mouse gene set with the same name, see GOCC_WEIBEL_PALADE_BODY

Standard name GOCC_WEIBEL_PALADE_BODY
Systematic name M25779
Brief description A large, elongated, rod-shaped secretory granule characteristic of vascular endothelial cells that contain a number of structurally and functionally distinct proteins, of which the best characterized are von Willebrand factor (VWF) and P-selectin. Weibel-Palade bodies are formed from the trans-Golgi network in a process that depends on VWF, which is densely packed in a highly organized manner, and on coat proteins that remain associated with the granules. Upon cell stimulation, regulated exocytosis releases the contained proteins to the cell surface, where they act in the recruitment of platelets and leukocytes and in inflammatory and vasoactive responses. [PMID:11935287, PMID:16087708]
Full description or abstract  
Collection C5: Ontology
      GO: Gene Ontology
            GO:CC: GO Cellular Component
Source publication  
Exact source GO:0033093
Related gene sets  
External links http://amigo.geneontology.org/amigo/term/GO:0033093
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Source species Homo sapiens
Contributed by Gene Ontology (Gene Ontology Consortium)
Source platform or
identifier namespace
Human_NCBI_Gene_ID
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