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Systematic name M432
Brief description Genes down-regulated in neutrophils isolated from: healthy versus patients with peridontitis.
Full description or abstract Peripheral blood neutrophils from periodontitis patients exhibit a hyper-reactive and hyper-active phenotype (collectively termed hyper-responsivity) in terms of production of reactive oxygen species (ROS) however the molecular basis for this observation is yet to be determined. Our objectives were to identify genes differentially expressed in hyper-responsive peripheral blood neutrophils from chronic periodontitis patients relative to periodontally healthy controls and use this data to identify potential contributory pathways to the hyper-responsive neutrophil phenotype.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 18832737   Authors: Wright HJ,Matthews JB,Chapple IL,Ling-Mountford N,Cooper PR
Exact source GSE12484_2752_200_DN
Related gene sets (show 1 additional gene sets from the source publication)

(show 4 gene sets from the same authors)
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Organism Homo sapiens
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform HUMAN_GENE_SYMBOL
Dataset references (show 1 datasets)
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Compendia expression profiles ? GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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