Human Gene Set: GSE13493_CD4INTCD8POS_VS_CD8POS_THYMOCYTE_DN

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Standard name GSE13493_CD4INTCD8POS_VS_CD8POS_THYMOCYTE_DN
Systematic name M3317
Brief description Genes down-regulated in comparison of CD4 [GeneID=920] CD8 Int thymocytes versus CD8 thymocytes.
Full description or abstract T cell development relies on the precise developmental control of various cellular functions for appropriate positive and negative selection. Previously, gene expression profiling of peptide-driven negative selection events in the N15 TCR class I MHC-restricted mouse and D011.10 TCR class II MHC-restricted mouse has offered insights into the coordinate engagement of biological processes affecting thymocyte development. However, there has been little comparable detailed in vivo global genome expression analysis reported for positive selection. We used microarrays to identify the genes differentially expressed during CD8 single positive T cell development in N15 TCR transgenic Rag2 deficient mice.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 19027330   Authors: Choi YI,Duke-Cohan JS,Ahmed WB,Handley MA,Mann F,Epstein JA,Clayton LK,Reinherz EL
Exact source GSE13493_1527_200_DN
Related gene sets (show 5 additional gene sets from the source publication)
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Organism Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform HUMAN_GENE_SYMBOL
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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