Human Gene Set: GSE14413_UNSTIM_VS_IFNB_STIM_NIH3T3_CELLS_DN


Standard name GSE14413_UNSTIM_VS_IFNB_STIM_NIH3T3_CELLS_DN
Systematic name M471
Brief description Genes down-regulated in NIH3T3 cells (fibroblast): control versus stimulated with IFN-b.
Full description or abstract Cytoplasmic DNA triggers the activation of the innate immune system. While downstream signaling components have been characterized, the DNA sensing components remain largely elusive. We performed a systematic proteomics screen for proteins that associate with DNA, traversed to a screen for IFN-?-induced transcripts. We identified DSIRE (DNA sensor for the IL-1? response, previously called AIM2) as a candidate cytoplasmic sensor. DSIRE showed a marked selectivity for double-stranded DNA. DSIRE can recruit the inflammasome adaptor ASC and gets redistributed to ASC speckles upon coexpression of ASC. RNAi-mediated reduction of DSIRE expression led to an impairment in IL-1? maturation. Reconstitution of unresponsive cells with DSIRE, ASC, caspase 1 and IL-1? showed that DSIRE is sufficient for inflammasome activation. Overall, our data strongly suggest that DSIRE is a cytoplasmic DNA sensor for the inflammasome.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 19158679   Authors: Bürckstümmer T,Baumann C,Blüml S,Dixit E,Dürnberger G,Jahn H,Planyavsky M,Bilban M,Colinge J,Bennett KL,Superti-Furga G
Exact source GSE14413_1127_200_DN
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Source species Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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