Systematic name M2956
Brief description Genes down-regulated in induced T reg cultured with IL2 [GeneID=3558]: wildtype versus non-functional FOXP3 [GeneID=50943].
Full description or abstract The gene expression profile of peripheral Foxp3+ natural regulatory T cells isolated from Foxp3/EGFP bicistronic mice was compared to that of in vitro-induced regulatory T cells and to CD4+ conventional (Foxp3-) T cells. The role of the regulatory T cell transcription factor Foxp3 in shaping the transcriptosomes of natural and induced regulatory T cells was analyzed using mice expressing a mutant FOXP3-EGFP fusion protein (Foxp3deltaEGFP). We used gene expression microarrays to examine the transcriptional programs of natural and induced regulatory T cells and the function of Foxp3 in organizing the transcriptosomes of the respective cell type
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 19265124   Authors: Haribhai D,Lin W,Edwards B,Ziegelbauer J,Salzman NH,Carlson MR,Li SH,Simpson PM,Chatila TA,Williams CB
Exact source GSE14415_2987_200_DN
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Source species Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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