Systematic name M7166
Brief description Genes up-regulated in memory CD8 T cells: wildtype wt versus ZBTB7B [GeneID=51043] knockout.
Full description or abstract We noticed that ThPOK repression is readily abrogated upon in vitro TCR stimulation of peripheral CD8 T cells. This observation prompted us to investigate a role of ThPOK in the CD8 T cell response to an acute viral infection. We observed that clonal expansion is significantly less in both primary and secondary CD8 T cell responses in the absence of functional ThPOK. To approach this mechanism, we carried out a microarray analysis for comparison of gene expression between ThPOKhd/hd and ThPOKwt/wt P14 memory T cells.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 19734230   Authors: Setoguchi R,Taniuchi I,Bevan MJ
Exact source GSE17812_2733_200_UP
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(show 12 gene sets from the same authors)
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Source species Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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