Human Gene Set: GSE18893_TCONV_VS_TREG_24H_TNF_STIM_UP

Standard name GSE18893_TCONV_VS_TREG_24H_TNF_STIM_UP
Systematic name M7308
Brief description Genes up-regulated in lymphocytes treated with TNF [GeneID=7124] for 24h: T conv versus T reg cells.
Full description or abstract Here we show that tumor necrosis factor (TNF) induced in human T-regulatory cells (Treg), as compared to conventional T cells (Tcon), a transcription program highly enriched for typical NF-?B target genes, such as: the cytokines LTA and TNF; the TNF-receptor super family members FAS, 4-1BB and OX-40; various anti-apoptotic genes; and other important immune-response genes. As an initial approach to examine the cellular program induced by TNF in Tregs versus Tcon cells, we employed microarray gene expression analysis at 2 and 24 hrs following TNF treatment.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 20181891   Authors: Nagar M,Jacob-Hirsch J,Vernitsky H,Berkun Y,Ben-Horin S,Amariglio N,Bank I,Kloog Y,Rechavi G,Goldstein I
Exact source GSE18893_1280_200_UP
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Source species Homo sapiens
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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