Human Gene Set: GSE20754_WT_VS_TCF1_KO_MEMORY_CD8_TCELL_DN

GSEA and MSigDB Need Your Support

We are preparing a grant proposal to NCI's Information Technology for Cancer Research program for the continued funding of GSEA and MSigDB. Click here to learn how you can help. (show)


Standard name GSE20754_WT_VS_TCF1_KO_MEMORY_CD8_TCELL_DN
Systematic name M7782
Brief description Genes down-regulated in memory CD8 T cells: wildtype versus TCF7 [GeneID=6932] knockout.
Full description or abstract TCF-1 is an HMG family transcription factor which is known to be activated by the canonical Wnt signaling pathway and modulated by other signals such as those derived from T cell receptor. We found that during CD8 T cell responses, TCF-1 deficiency impaired long-term maintenance of antigen-specific memory CD8 T cells. We used microarrays to detect gene expression changes in memory CD8 T cells caused by TCF-1 deficiency.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 20727791   Authors: Zhou X,Yu S,Zhao DM,Harty JT,Badovinac VP,Xue HH
Exact source GSE20754_2450_200_DN
Related gene sets (show 1 additional gene sets from the source publication)

(show 77 gene sets from the same authors)
External links  
Filtered by similarity ?
Organism Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform HUMAN_GENE_SYMBOL
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 199 genes
Gene families ? Categorize these 199 genes by gene family
Show members (show 200 members mapped to 199 genes)
Version history 7.3: Moved to ImmuneSigDB sub-collection.

See MSigDB license terms here. Please note that certain gene sets have special access terms.