Human Gene Set: GSE22033_WT_VS_PPARG_KO_MEF_DN

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Standard name GSE22033_WT_VS_PPARG_KO_MEF_DN
Systematic name M7692
Brief description Genes down-regulated in mouse embryonic fibroblasts (MEF): wildtype versus PPARG [GeneID=5468] knockout.
Full description or abstract In order to identify the molecular mechanisms of PPARgamma phosphorylation at Set273, we generated cell-lines of PPARgamma KO MEFs expressing wtPPARgamma or S273APPARgamma. In addition, because our data showed that PPARgamma ligand drugs such as rosiglitazone and MRL24 blocked this phopshorylation, we treated cells with these drugs, then prepared RNA samples to look at the gene profiling.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 20651683   Authors: Choi JH,Banks AS,Estall JL,Kajimura S,Boström P,Laznik D,Ruas JL,Chalmers MJ,Kamenecka TM,Blüher M,Griffin PR,Spiegelman BM
Exact source GSE22033_2268_200_DN
Related gene sets (show 5 additional gene sets from the source publication)
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Organism Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform HUMAN_GENE_SYMBOL
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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