Systematic name M7486
Brief description Genes up-regulated in periperal blood monocytes (PBMC): tolerant kidney transplants versus healthy controls.
Full description or abstract In this study, investigators recruited the largest reported cohort of tolerant kidney transplant recipients who maintained their graft after ceasing to take their immunosuppression drug, and compared this cohort to subjects with stable allograft function while on immunosuppression and healthy non transplated, controls. Using gene expression studies, they identified genetic markers that are strong candidates for predicting kidney transplant candidates who may benefit from minimization or withdrawl of immunosuppression. Microarrays were used to detect expressed gene profiles of whole-blood total RNA from subjects in the tolerant, standard immunotherapy and healthy control participants
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 20501946   Authors: Newell KA,Asare A,Kirk AD,Gisler TD,Bourcier K,Suthanthiran M,Burlingham WJ,Marks WH,Sanz I,Lechler RI,Hernandez-Fuentes MP,Turka LA,Seyfert-Margolis VL,Immune Tolerance Network ST507 Study Group
Exact source GSE22229_2396_200_UP
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Source species Homo sapiens
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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