Human Gene Set: GSE23308_WT_VS_MINERALCORTICOID_REC_KO_MACROPHAGE_DN

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Standard name GSE23308_WT_VS_MINERALCORTICOID_REC_KO_MACROPHAGE_DN
Systematic name M7740
Brief description Genes down-regulated in macrophages: wildtype versus NR3C2 [GeneID=4306] knockout.
Full description or abstract Inappropriate excess of the steroid hormone aldosterone, which is a mineralocorticoid receptor (MR) agonist, is associated with increased inflammation and risk of cardiovascular disease. MR antagonists are cardioprotective and antiinflammatory in vivo, and evidence suggests that they mediate these effects in part by aldosterone- independent mechanisms. We used affymetrix to characterize the effect of Mineralocorticoid Receptor deletion on macrophage transcriptional profile, and identify its requirement in normal glucocorticoid signalling.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 20697155   Authors: Usher MG,Duan SZ,Ivaschenko CY,Frieler RA,Berger S,Schütz G,Lumeng CN,Mortensen RM
Exact source GSE23308_3374_200_DN
Related gene sets (show 7 additional gene sets from the source publication)
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Organism Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform HUMAN_GENE_SYMBOL
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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