Human Gene Set: GSE23695_CD57_POS_VS_NEG_NK_CELL_DN

Standard name GSE23695_CD57_POS_VS_NEG_NK_CELL_DN
Systematic name M7786
Brief description Genes down-regulated in NK cells: B3GAT1+ [GeneID=27087] versus B3GAT1- [GeneID=27087].
Full description or abstract Thirty to 60% of CD56dimCD16bright NK cells in healthy adults express CD57, which is not expressed on immature CD56bright NK cells or fetal and newborn NK cells. We hypothesized that CD57+ NK cells within the CD56dim mature NK cell subset are highly mature and might be terminally differentiated. We used microarrays to assess the transcriptional differences between CD57+ and CD57neg NK cells within the CD56dim mature NK subset.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 20733159   Authors: Lopez-Vergès S,Milush JM,Pandey S,York VA,Arakawa-Hoyt J,Pircher H,Norris PJ,Nixon DF,Lanier LL
Exact source GSE23695_3368_200_DN
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Source species Homo sapiens
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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