Human Gene Set: GSE25677_MPL_VS_MPL_AND_R848_STIM_BCELL_DN


Standard name GSE25677_MPL_VS_MPL_AND_R848_STIM_BCELL_DN
Systematic name M8181
Brief description Genes down-regulated in B lymphocytes immunized with: monophosphoryl lipid A (MPL) versus MPL and imiquimod [PubChem=13982876].
Full description or abstract Many successful vaccines induce persistent antibody responses that can last a lifetime. The mechanisms by which they do so remain unclear, but emerging evidence suggests that activate dendritic cells (DCs) via Toll-like receptors (TLRs). For example, the yellow fever vaccine YF-17D, one of the most successful empiric vaccines ever developed, activates DCs via multiple TLRs to stimulate pro-inflammatory cytokines. Triggering specific combinations of TLRs in DCs can induce synergistic production of cytokines, which results in enhanced T cell responses, but its impact on antibody responses remain unknown. Learning the critical parameters of innate immunity that programs such antibody responses remains a major challenge in vaccinology. We demonstrated that immunization of mice with synthetic nanoparticles containing antigens plus Toll-like receptor (TLR) ligands 4 (MPL) + 7 (R837) induces synergistic increases in antigen-specific, neutralizing antibodies compared to immunization with a single TLR ligand. To determine whether there was any early programming of B cells, we isolated isotype switched, TCRbeta-CD11b-CD19+IgD-IgG+ B cells by FACS at 7 days post immunization with nanoparticles containing various adjuvants plus OVA, and performed microarray analyses to assess their molecular signatures.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 21350488   Authors: Kasturi SP,Skountzou I,Albrecht RA,Koutsonanos D,Hua T,Nakaya HI,Ravindran R,Stewart S,Alam M,Kwissa M,Villinger F,Murthy N,Steel J,Jacob J,Hogan RJ,García-Sastre A,Compans R,Pulendran B
Exact source GSE25677_1568_200_DN
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Source species Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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