Systematic name M8136
Brief description Genes down-regulated in cytotoxic T cells: wildtype versus PDK1 [GeneID=5163] knockout.
Full description or abstract In cytotoxic T cells (CTL), Protein Kinase B /Akt is activated by the T cell antigen receptor (TCR) and the cytokine Interleukin 2 (IL2), in part by phosophorylation of Akt by Phospholipid dependent kinase 1 (PDK1). The role of PDK1 and Akt in CTL has however not been fully defined. In order to explore the relative roles of these kinases in CTL we used microarrays to profile the gene expression of control and PDK1 null CTL. In separate experiments we compared the gene expression profiles of control and Akt inhibitor treated CTL.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 21295499   Authors: Macintyre AN,Finlay D,Preston G,Sinclair LV,Waugh CM,Tamas P,Feijoo C,Okkenhaug K,Cantrell DA
Exact source GSE26290_2398_200_DN
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Source species Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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