Human Gene Set: GSE28237_FOLLICULAR_VS_EARLY_GC_BCELL_DN

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Standard name GSE28237_FOLLICULAR_VS_EARLY_GC_BCELL_DN
Systematic name M4885
Brief description Genes down-regulated in comparison of naive follicular B cells versus early germinal center (GC) B cells.
Full description or abstract Upon immunization with a T cell dependent antigen naive follicular B cells (Fo) are activated and a germinal center reaction is induced. Within the next 2 weeks large germinal centers develop where the process of affinity maturation takes place. To analyze the gene expression profile of resting and activated B cells, follicular B cells (Fo), B cells from early (GC1) and late germinal centers (GC2) were isolated and their gene expression profile compared.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 20518031   Authors: Wilke G,Steinhauser G,Grün J,Berek C
Exact source GSE28237_1750_200_DN
Related gene sets (show 5 additional gene sets from the source publication)
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Organism Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform HUMAN_GENE_SYMBOL
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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