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Systematic name M8527
Brief description Genes up-regulated in macrophages: resting differentiated versus alternatively activated M2.
Full description or abstract In response to microenvironmental signals macrophages undergo different activation, indicated as classic/M1 and alternative/M2 polarization. C-Myc transcription factor could be an essential player in M2 polarization. Functional relevance of c-Myc in M2 macrophage biology is investigated by evaluating the effect of 100-58F4, on the transcriptional profile induced on human macrophages by IL-4.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 22067385   Authors: Pello OM,De Pizzol M,Mirolo M,Soucek L,Zammataro L,Amabile A,Doni A,Nebuloni M,Swigart LB,Evan GI,Mantovani A,Locati M
Exact source GSE32164_3500_200_UP
Related gene sets (show 5 additional gene sets from the source publication)

(show 15 gene sets from the same authors)
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Organism Homo sapiens
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform HUMAN_GENE_SYMBOL
Dataset references (show 1 datasets)
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Compendia expression profiles ? GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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