Systematic name M9414
Brief description Genes up-regulated in CD8A [GeneID=935] dendritic cells: untreated versus poly(IC).
Full description or abstract The injection of the pathogen-associated molecular pattern Polyinosinic-polycytidylic acid (poly(I:C)) leads to the activation of various immune cells, including dendritic cells (DCs) and Natural Killer (NK) cells. This activation is due to different innate cytokines produced early after injection, in particular IFN-I. The objective of the study was to compare the pattern of expression of IFN-I stimulated genes between DC and NK cells. The project focused on a specific subset of conventional DC, CD8a DC, which responsiveness to IFN-I determines the capacity to activate CD8 T cells by cross-presentation of exogenous antigens. To identify the responses to IFN-I selectively induced in CD8a+ DC, we compared their gene expression profile to that of NK cells, using gene chips, before and after poly(I:C) stimulation.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 23084923   Authors: Baranek T,Manh TP,Alexandre Y,Maqbool MA,Cabeza JZ,Tomasello E,Crozat K,Bessou G,Zucchini N,Robbins SH,Vivier E,Kalinke U,Ferrier P,Dalod M
Exact source GSE39556_3193_200_UP
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Source species Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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