Human Gene Set: GSE4142_NAIVE_VS_GC_BCELL_DN


Standard name GSE4142_NAIVE_VS_GC_BCELL_DN
Systematic name M6377
Brief description Genes down-regulated in B lymphocytes: naïve versus germinal center.
Full description or abstract In order to better understand the factors that regulate B cell differentiation upon exposure to antigen, we compares global gene expression profiles from naive B cells with antigen-specific plasma, germinal center, and memory B cells after immunization with the T-dependent antigen, NP-CGG. The memory B cell-enriched transcripts were then compared with memory T cell-enriched and hematopoietic stem cell-enriched transcripts in order to generate a transcriptional profile of self-renewal within the hematopoietic system.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 16492737   Authors: Luckey CJ,Bhattacharya D,Goldrath AW,Weissman IL,Benoist C,Mathis D
Exact source GSE4142_3223_200_DN
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Source species Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
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identifier namespace		 HUMAN_GENE_SYMBOL
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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