Human Gene Set: GSE6259_DEC205_POS_DC_VS_CD8_TCELL_DN

Standard name GSE6259_DEC205_POS_DC_VS_CD8_TCELL_DN
Systematic name M6776
Brief description Genes down-regulated in splenic DEC205+ dendritic cells versus CD8 T cells.
Full description or abstract Dendritic cells (DCs) process and present self and foreign antigens to induce tolerance or immunity. In vitro models suggest that induction of immunity is controlled by regulating the presentation of antigen, but little is known about how DCs control antigen presentation in vivo. To examine antigen processing and presentation in vivo we specifically targeted antigens to the two major subsets of DCs using chimeric monoclonal antibodies. Unlike CD8+ DCs that express the cell surface protein CD205, CD8- DCs, which are positive for the 33D1 antigen, are specialized for presentation on MHC class II. This difference in antigen processing is intrinsic to the DC subsets and associated with increased expression of proteins associated with MHC processing.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 17204652   Authors: Dudziak D,Kamphorst AO,Heidkamp GF,Buchholz VR,Trumpfheller C,Yamazaki S,Cheong C,Liu K,Lee HW,Park CG,Steinman RM,Nussenzweig MC
Exact source GSE6259_2695_200_DN
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Source species Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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