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Systematic name M463
Brief description Genes down-regulated in CD4 [GeneID=920] T cells: control versus IL6 [GeneID=3569].
Full description or abstract IL-6, a proinflammtory cytokine produced by antigen presenting cells and non-hematopoietic cells in response to external stimuli, acts as an important bridge between the innate and adaptive immune responses. IL-6 together with IL-4 can promote Th2 polarization, while in combination with TGFbeta mediates Th17 differentiation. We examined early changes in gene expression in mouse CD4+ T cells induced by IL-6.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 19139170   Authors: Dienz O,Eaton SM,Bond JP,Neveu W,Moquin D,Noubade R,Briso EM,Charland C,Leonard WJ,Ciliberto G,Teuscher C,Haynes L,Rincon M
Exact source GSE7459_2237_200_DN
Related gene sets (show 1 additional gene sets from the source publication)

(show 38 gene sets from the same authors)
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Organism Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform HUMAN_GENE_SYMBOL
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
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Compendia expression profiles ? GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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