Human Gene Set: GSE8515_CTRL_VS_IL1_4H_STIM_MAC_DN

Standard name GSE8515_CTRL_VS_IL1_4H_STIM_MAC_DN
Systematic name M5760
Brief description Genes down-regulated in comparison of untreated macrophages versus those treated with IL1.
Full description or abstract Using whole-genome Affymetrix microarrays (HG-U133A), we characterized the transcriptome profile of cultured human macrophages stimulated for 4 h with interleukin 1 (IL-1) or interleukin 6 (IL-6). We found that, in distinction to liver cells, IL-1 is much more potent than IL-6 in modifying macrophage gene expression, although considerable heterogeneity in response of macrophages deriving from individual blood donors was observed. The obtained results permitted to identify a large number of cytokine-responsive genes. coding for proteins of unknown function that are now being studied in our laboratory. They may represent novel targets in the anti-inflammatory therapy.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 18498781   Authors: Jura J,Wegrzyn P,Korosty?ski M,Guzik K,Oczko-Wojciechowska M,Jarzab M,Kowalska M,Piechota M,Przew?ocki R,Koj A
Exact source GSE8515_1721_200_DN
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Source species Homo sapiens
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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