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Systematic name M5841
Brief description Genes down-regulated in comparison of exhausted CD8 T cells versus memory CD8 T cells.
Full description or abstract CD8 T cells normally differentiate from resting na´ve T cells into function effector and then memory CD8 T cells following acute infections. During chronic viral infections, however, virus-specific CD8 T cells often become exhausted. We used microarrays to examine the gene expression differences between naive, effector, memory and exhausted virus-specific CD8 T cells following lymphocytic choriomeningitis virus infection.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 17950003   Authors: Wherry EJ,Ha SJ,Kaech SM,Haining WN,Sarkar S,Kalia V,Subramaniam S,Blattman JN,Barber DL,Ahmed R
Exact source GSE9650_1258_200_DN
Related gene sets (show 13 additional gene sets from the source publication)

(show 357 gene sets from the same authors)
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Organism Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform HUMAN_GENE_SYMBOL
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Compendia expression profiles ? GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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