Gene Set: ICHIBA_GRAFT_VERSUS_HOST_DISEASE_35D_DN

Standard name ICHIBA_GRAFT_VERSUS_HOST_DISEASE_35D_DN
Systematic name M13337
Brief description Hepatic graft versus host disease (GVHD), day 35: genes down-regulated in allogeneic vs syngeneic bone marrow transplant.
Full description or abstract The liver, skin, and gastrointestinal tract are major target organs of acute graft-versus-host disease (GVHD), the major complication of allogeneic bone marrow transplantation (BMT). In order to gain a better understanding of acute GVHD in the liver, we compared the gene expression profiles of livers after experimental allogeneic and syngeneic BMT using oligonucleotide microarray. At 35 days after allogeneic BMT when hepatic GVHD was histologically evident, genes related to cellular effectors and acute-phase proteins were up-regulated, whereas genes largely related to metabolism and endocrine function were down-regulated. At day 7 after BMT before the development of histologic changes in the liver, interferon gamma (IFN-gamma)-inducible genes, major histocompatibility (MHC) class II molecules, and genes related to leukocyte trafficking had been up-regulated. Immunohistochemistry demonstrated that expression of IFN-gamma protein itself was increased in the spleen but not in hepatic tissue. These results suggest that the increased expression of genes associated with the attraction and activation of donor T cells induced by IFN-gamma early after BMT is important in the initiation of hepatic GVHD in this model and provide new potential molecular targets for early detection and intervention of acute GVHD.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 12663442   Authors: Ichiba T,Teshima T,Kuick R,Misek DE,Liu C,Takada Y,Maeda Y,Reddy P,Williams DL,Hanash SM,Ferrara JL
Exact source Suppl. data file 'BMT_356_public.xls': A35 vs S35 P<.01 and FC<0.5
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Organism Mus musculus
Contributed by Arthur Liberzon (MSigDB Team)
Source platform AFFY_MG_U74
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