Systematic name M1606
Brief description Genes in the expression cluster 'Early Progenitors Shared': up-regulated in hematopoietic progenitors from adult bone marrow and from fetal liver.
Full description or abstract Mechanisms regulating self-renewal and cell fate decisions in mammalian stem cells are poorly understood. We determined global gene expression profiles for mouse and human hematopoietic stem cells and other stages of the hematopoietic hierarchy. Murine and human hematopoietic stem cells share a number of expressed gene products, which define key conserved regulatory pathways in this developmental system. Moreover, in the mouse, a portion of the genetic program of hematopoietic stem cells is shared with embryonic and neural stem cells. This overlapping set of gene products represents a molecular signature of stem cells.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 12228721   Authors: Ivanova NB,Dimos JT,Schaniel C,Hackney JA,Moore KA,Lemischka IR
Exact source Excel Table 2S: Expression Cluster=Early Progenitors Shared
Related gene sets (show 7 additional gene sets from the source publication)
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Organism Mus musculus
Contributed by John Newman (University of Washington)
Source platform AFFY_MG_U74
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Compendia expression profiles GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Version history 3.0: Renamed from HSC_EARLYPROGENITORS_SHARED

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