Gene Set: IVANOVA_HEMATOPOIESIS_STEM_CELL

Standard name IVANOVA_HEMATOPOIESIS_STEM_CELL
Systematic name M6813
Brief description Genes in the expression cluster 'HSC Shared': up-regulated in hematopoietic stem cells (HSC) from adult bone marrow and fetal liver.
Full description or abstract Mechanisms regulating self-renewal and cell fate decisions in mammalian stem cells are poorly understood. We determined global gene expression profiles for mouse and human hematopoietic stem cells and other stages of the hematopoietic hierarchy. Murine and human hematopoietic stem cells share a number of expressed gene products, which define key conserved regulatory pathways in this developmental system. Moreover, in the mouse, a portion of the genetic program of hematopoietic stem cells is shared with embryonic and neural stem cells. This overlapping set of gene products represents a molecular signature of stem cells.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 12228721   Authors: Ivanova NB,Dimos JT,Schaniel C,Hackney JA,Moore KA,Lemischka IR
Exact source Excel Table 2S: Expression Cluster=HSC Shared
Related gene sets (show 7 additional gene sets from the source publication)
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Organism Mus musculus
Contributed by John Newman (University of Washington)
Source platform AFFY_MG_U74
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Version history 3.0: Renamed from HSC_HSC_SHARED

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