Gene Set: IVANOVSKA_MIR106B_TARGETS

Standard name IVANOVSKA_MIR106B_TARGETS
Systematic name M2258
Brief description A consensus set of genes that were significantly down-regulated by MIR106B [GeneID=406900].
Full description or abstract microRNAs in the miR-106b family are overexpressed in multiple tumor types and are correlated with the expression of genes that regulate the cell cycle. Consistent with these observations, miR-106b family gain of function promotes cell cycle progression, whereas loss of function reverses this phenotype. Microarray profiling uncovers multiple targets of the family, including the cyclin-dependent kinase inhibitor p21/CDKN1A. We show that p21 is a direct target of miR-106b and that its silencing plays a key role in miR-106b-induced cell cycle phenotypes. We also show that miR-106b overrides a doxorubicin-induced DNA damage checkpoint. Thus, miR-106b family members contribute to tumor cell proliferation in part by regulating cell cycle progression and by modulating checkpoint functions.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 18212054   Authors: Ivanovska I,Ball AS,Diaz RL,Magnus JF,Kibukawa M,Schelter JM,Kobayashi SV,Lim L,Burchard J,Jackson AL,Linsley PS,Cleary MA
Exact source Table 1S
Related gene sets (show 11 gene sets from the same authors)
External links  
Filtered by similarity
Organism Homo sapiens
Contributed by Arthur Liberzon (MSigDB Team)
Source platform HUMAN_SEQ_ACCESSION
Dataset references (show 1 datasets)
Download gene set format: grp | text | gmt | gmx | xml
Compute overlaps (show collections to investigate for overlap with this gene set)
Compendia expression profiles GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 88 genes
Gene families Categorize these 88 genes by gene family
Show members (show 90 members mapped to 88 genes)
Version history 3.1: First introduced

See MSigDB license terms here. Please note that certain gene sets have special access terms.