Human Gene Set: JACKSON_DNMT1_TARGETS_DN

For the Mouse gene set with the same name, see JACKSON_DNMT1_TARGETS_DN

Standard name JACKSON_DNMT1_TARGETS_DN
Systematic name M1627
Brief description Genes down-regulated in MEF cells (embryonic fibroblast) upon Cre-lox knockout of DNMT1 [GeneID=1786].
Full description or abstract Cytosine methylation of mammalian DNA is essential for the proper epigenetic regulation of gene expression and maintenance of genomic integrity. To define the mechanism through which demethylated cells die, and to establish a paradigm for identifying genes regulated by DNA methylation, we have generated mice with a conditional allele for the maintenance DNA methyltransferase gene Dnmt1. Cre-mediated deletion of Dnmt1 causes demethylation of cultured fibroblasts and a uniform p53-dependent cell death. Mutational inactivation of Trp53 partially rescues the demethylated fibroblasts for up to five population doublings in culture. Oligonucleotide microarray analysis showed that up to 10% of genes are aberrantly expressed in demethylated fibroblasts. Our results demonstrate that loss of Dnmt1 causes cell-type-specific changes in gene expression that impinge on several pathways, including expression of imprinted genes, cell-cycle control, growth factor/receptor signal transduction and mobilization of retroelements.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 11137995   Authors: Jackson-Grusby L,Beard C,Possemato R,Tudor M,Fambrough D,Csankovszki G,Dausman J,Lee P,Wilson C,Lander E,Jaenisch R
Exact source Table 2: Fold <= -2
Related gene sets (show 1 additional gene sets from the source publication)

(show 56 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Mus musculus
Contributed by John Newman (University of Washington)
Source platform or
identifier namespace
AFFY_Mu11K
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 21 genes
Gene families ? Categorize these 21 genes by gene family
Show members (show 27 source identifiers mapped to 21 genes)
Version history 3.1: First introduced

See MSigDB license terms here. Please note that certain gene sets have special access terms.