Gene Set: JACKSON_DNMT1_TARGETS_UP

Standard name JACKSON_DNMT1_TARGETS_UP
Systematic name M1604
Brief description Genes up-regulated in MEF cells (embryonic fibroblast) upon Cre-lox knockout of DNMT1 [GeneID=1786].
Full description or abstract Cytosine methylation of mammalian DNA is essential for the proper epigenetic regulation of gene expression and maintenance of genomic integrity. To define the mechanism through which demethylated cells die, and to establish a paradigm for identifying genes regulated by DNA methylation, we have generated mice with a conditional allele for the maintenance DNA methyltransferase gene Dnmt1. Cre-mediated deletion of Dnmt1 causes demethylation of cultured fibroblasts and a uniform p53-dependent cell death. Mutational inactivation of Trp53 partially rescues the demethylated fibroblasts for up to five population doublings in culture. Oligonucleotide microarray analysis showed that up to 10% of genes are aberrantly expressed in demethylated fibroblasts. Our results demonstrate that loss of Dnmt1 causes cell-type-specific changes in gene expression that impinge on several pathways, including expression of imprinted genes, cell-cycle control, growth factor/receptor signal transduction and mobilization of retroelements.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 11137995   Authors: Jackson-Grusby L,Beard C,Possemato R,Tudor M,Fambrough D,Csankovszki G,Dausman J,Lee P,Wilson C,Lander E,Jaenisch R
Exact source Table 2: Fold >= 2
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Organism Mus musculus
Contributed by John Newman (University of Washington)
Source platform AFFY_Mu11K
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Version history 3.1: First introduced

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