Human Gene Set: JIANG_AGING_HYPOTHALAMUS_DN

For the Mouse gene set with the same name, see JIANG_AGING_HYPOTHALAMUS_DN

Standard name JIANG_AGING_HYPOTHALAMUS_DN
Systematic name M1535
Brief description Down-regulated in the hypothalamus of aged (22 months) BALB/c mice, compared to young (2 months) controls
Full description or abstract A better understanding of the molecular effects of aging in the brain may help to reveal important aspects of organismal aging, as well as processes that lead to age-related brain dysfunction. In this study, we have examined differences in gene expression in the hypothalamus and cortex of young and aged mice by using high-density oligonucleotide arrays. A number of key genes involved in neuronal structure and signaling are differentially expressed in both the aged hypothalamus and cortex, including synaptotagmin I, cAMP-dependent protein kinase C beta, apolipoprotein E, protein phosphatase 2A, and prostaglandin D. Misregulation of these proteins may contribute to age-related memory deficits and neurodegenerative diseases. In addition, many proteases that play essential roles in regulating neuropeptide metabolism, amyloid precursor protein processing, and neuronal apoptosis are up-regulated in the aged brain and likely contribute significantly to brain aging. Finally, a subset of these genes whose expression is affected by aging are oppositely affected by exposure of mice to an enriched environment, suggesting that these genes may play important roles in learning and memory.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 11172053   Authors: Jiang CH,Tsien JZ,Schultz PG,Hu Y
Exact source Table 1, 3S: FC < -2
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Source species Mus musculus
Contributed by John Newman (University of Washington)
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identifier namespace		 AFFY_Mu11K
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Version history 3.1: First introduced

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