Gene Set: JINESH_BLEBBISHIELD_TO_IMMUNE_CELL_FUSION_PBSHMS_DN

Standard name JINESH_BLEBBISHIELD_TO_IMMUNE_CELL_FUSION_PBSHMS_DN
Systematic name M38970
Brief description Genes Downregulated in PBSHMS (RT4 blebbishield-to-immune cell fusion)
Full description or abstract Apoptosis is a process that kills cells. However, cancer stem cells find ways to escape death after commencement of apoptosis. One such mechanism is blebbishield emergency program, in which the apoptotic cancer stem cells first undergo apoptotic body formation but then reassemble apoptotic bodies with main body (nuclei containing) of the apoptotic cells to form spherical to elongated structures called blebbishields. Blebbishields in turn are capable of blebbishield-blebbishield fusion to form transformed stem cell spheres (transformation phase) and then give rise to individual cancer cells from spheres (exit phase). Blebbishields are also capable of fusion with immune cells. The resulting hybrids are called PBSHMS cells in this study. We did microarray analysis of live RT4 cells, and hybrid PBSHMS cells. This data set is a comparison of RT4 cells, and hybrid PBSHMS cells and the gene list includes the genes that are downregulated in blebbishield-immune cells hybrids (PBSHMS). A separate set is provided for upregulated gene list too.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 28855211
Exact source Supplementary table-2 & Figure-3D Genes Downregulated in PBSHMS (blebbishield-to-immune cell fusion) Log2Fold change <0.6
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Organism Homo sapiens
Contributed by Goodwin G. Jinesh and Ashish M. Kamat (UT MD Anderson Cancer Center)
Source platform Human_ILLUMINA_Array
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Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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