Gene Set: JINESH_BLEBBISHIELD_TRANSFORMED_STEM_CELL_SPHERES_DN

Standard name JINESH_BLEBBISHIELD_TRANSFORMED_STEM_CELL_SPHERES_DN
Systematic name M38975
Brief description Genes Down-regulated in transformed spheres compared to blebbishields from RT4 cells
Full description or abstract Apoptosis is a process that kills cells. However, cancer stem cells find ways to escape death after commencement of apoptosis. One such mechanism is blebbishield emergency program, in which the apoptotic cancer stem cells first undergo apoptotic body formation but then reassemble apoptotic bodies with main body (nuclei containing) of the apoptotic cells to form spherical to elongated structures called blebbishields. Blebbishields in turn are capable of blebbishield-blebbishield fusion to form transformed stem cell spheres (transformation phase) and then give rise to individual cancer cells from spheres (exit phase). We identified blebbishield emergency program in RT4 bladder cancer cells (RT4P=P stands for parental) and did microarray analysis of live RT4P cells, blebbishields and transformed spheres. This data set is a comparison of blebbishields with transformed spheres and the gene list includes the genes that are downregulated in transformed spheres. A separate set is provided for upregulated gene list too. In addition we provide separate gene lists for upregulated and downregulated gene lists for blebbishields compared to RT4 live cells.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 28855211
Exact source Supplementary Table-1 & Figure-2B Genes Downregulated in transformed stem cell spheres Log2Fold change <1.0
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Organism Homo sapiens
Contributed by Goodwin G. Jinesh and Ashish M. Kamat (UT MD Anderson Cancer Center)
Source platform Human_ILLUMINA_Array
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Compendia expression profiles GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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