Systematic name M38973
Brief description Genes down-regulated in blebbishields compared to control RT4 live cells
Full description or abstract Apoptosis is a process that kills cells. However, cancer stem cells find ways to escape death after commencement of apoptosis. One such mechanism is blebbishield emergency program, in which the apoptotic cancer stem cells first undergo apoptotic body formation but then reassemble apoptotic bodies with main body (nuclei containing) of the apoptotic cells to form spherical to elongated structures called blebbishields. Blebbishields in turn are capable of blebbishield-blebbishield fusion to form transformed stem cell spheres (transformation phase) and then give rise to individual cancer cells from spheres (exit phase). We identified blebbishield emergency program in RT4 bladder cancer cells (RT4P=parental) and did microarray analysis of live RT4P cells, blebbishields and transformed spheres. This data set is a comparison of RT4P live cells with blebbishields and the gene list includes the genes that are downregulated in blebbishields. A separate set is provided for upregulated gene list too. In addition we provide separate gene lists for upregulated and downregulated gene lists for transformed spheres compared to blebbishields.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 28855211
Exact source Figure-2B: Genes downregulated in blebbishields Log2Fold change <1.0
Related gene sets (show 5 additional gene sets from the source publication)
External links  
Filtered by similarity
Organism Homo sapiens
Contributed by Goodwin G. Jinesh and Ashish M. Kamat (UT MD Anderson Cancer Center)
Source platform Human_ILLUMINA_Array
Dataset references (show 1 datasets)
Download gene set format: grp | text | gmt | gmx | xml
Compute overlaps (show collections to investigate for overlap with this gene set)
Compendia expression profiles GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 308 genes
Gene families Categorize these 308 genes by gene family
Show members (show 381 members mapped to 308 genes)
Version history  

See MSigDB license terms here. Please note that certain gene sets have special access terms.