Standard name KALMA_E2F1_TARGETS
Systematic name M10142
Brief description DNA replication genes up-regulated in a Rat-1a cell line (fibroblast) by expression of E2F1 [GeneID=1869].
Full description or abstract The transcription factor E2F-1 plays a pivotal role in the regulation of G1/S transition in higher eukaryotes cell cycle. We used a cell line containing an inducible E2F-1 and oligonucleotide microarray analysis to identify novel E2F target genes. We show that E2F-1 up-regulates the expression of a number of genes coding for components of the DNA replication machinery. Among them is the gene coding for the 32 Kd subunit of replication protein A (RPA2). Replication protein A is the most abundant single strand DNA binding complex and it is essential for DNA replication. We demonstrate that RPA2 is a novel E2F target gene whose expression can be directly regulated by E2F-1 via E2F binding sites in its promoter. In addition, expression of Topoisomerase IIalpha and subunit IV of DNA polymerase alpha is also up-regulated upon E2F-1 induction. Taken together, these results provide novel links between components of the DNA replication machinery and the cell growth regulatory pathway involving the Rb tumor suppressor and E2F.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 11313881   Authors: Kalma Y,Marash L,Lamed Y,Ginsberg D
Exact source Table 1: full names changed to symbols
Related gene sets  
External links  
Filtered by similarity
Organism Rattus norvegicus
Contributed by John Newman (University of Washington)
Source platform HUMAN_GENE_SYMBOL
Dataset references  
Download gene set format: grp | text | gmt | gmx | xml
Compute overlaps (show collections to investigate for overlap with this gene set)
Compendia expression profiles GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 11 genes
Gene families Categorize these 11 genes by gene family
Show members (show 11 members mapped to 11 genes)
Version history 3.0: Renamed from E2F1_DNA_UP

See MSigDB license terms here. Please note that certain gene sets have special access terms.