Human Gene Set: KANNAN_BLOOD_2012_2013_TIV_AGE_65PLS
      _REVACCINATED_IN_6_9_MO_VS_REVACCINATED
      _IN_12_13_MO_UP

GSEA and MSigDB Need Your Support

We are preparing a grant proposal to NCI's Information Technology for Cancer Research program for the continued funding of GSEA and MSigDB. Click here to learn how you can help. (show)


Standard name KANNAN_BLOOD_2012_2013_TIV_AGE_65PLS_REVACCINATED_IN_6_9_MO_VS_REVACCINATED_IN_12_13_MO_UP
Systematic name M40962
Brief description Genes up-regulated in blood cohort 1 (re-vaccinated in 6-9 months) vs cohort 2 (re-vaccinated in 12-13 months) in adults (65+) after exposure to 2012-2013 seasonal trivalent inactivated influenza vaccine (TIV) , time point N/A. Comment: Cohort 1 (re-vaccinated in 6-9 months) vs Cohort 2 (re-vaccinated in 12-13 months)
Full description or abstract We tested antibody responses to the trivalent inactivated influenza vaccine (TIV) in 34 aged individuals ( > 65 yrs) during the 2012/13 vaccination seasons. Nearly all had been vaccinated the previous year although the time interval between the two vaccine doses differed. One subgroup was re-vaccinated in 2012/13 within 6-9 months of their 2011/12 vaccination, the other received the two doses of vaccine in the typical ~12 month interval. Unexpectedly the sub-cohort with early revaccination exhibited significantly increased response rates and antibody titers to TIV compared to their normally re-vaccinated aged counter parts. Microarray analyses of gene expression in whole blood RNA taken at the day of the 2012/13 re-vaccination revealed statistically significant differences in expression of 754 genes between the individuals with early re-vaccination compared to subjects vaccinated in a normal 12 month interval. These observations suggest that TIV has long-lasting effects on the immune system affecting B cell responses as well as the transcriptome of peripheral blood mononuclear cells and this residual effect may augment vaccination response in patients where the effect of the previous vaccination has not yet diminished.
Collection C7: Immunologic Signature
      VAX: HIPC Vaccine Response
Source publication Pubmed 26637961   Authors: Kannan S,Kossenkov A,Kurupati RK,Xiang JZ,Doyle SA,Schmader KE,Schowe L,Ertl HC
Exact source Suppl Table, see also Fig 3
Related gene sets (show 1 additional gene sets from the source publication)

(show 16 gene sets from the same authors)
External links https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712333/bin/aging-07-1077-s001.xlsx
Filtered by similarity ?
Organism Homo sapiens
Contributed by HIPC SIGNATURES (NIAID/HIPC SIGNATURES)
Source platform HUMAN_GENE_SYMBOL
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 226 genes
Gene families ? Categorize these 226 genes by gene family
Show members (show 226 members mapped to 226 genes)
Version history 7.3: First Introduced.

See MSigDB license terms here. Please note that certain gene sets have special access terms.