Human Gene Set: KANNAN_BLOOD_2012_2013_TIV_AGE_65PLS

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Systematic name M40962
Brief description Genes up-regulated in blood cohort 1 (re-vaccinated in 6-9 months) vs cohort 2 (re-vaccinated in 12-13 months) in adults (65+) after exposure to 2012-2013 seasonal trivalent inactivated influenza vaccine (TIV) , time point N/A. Comment: Cohort 1 (re-vaccinated in 6-9 months) vs Cohort 2 (re-vaccinated in 12-13 months)
Full description or abstract We tested antibody responses to the trivalent inactivated influenza vaccine (TIV) in 34 aged individuals ( > 65 yrs) during the 2012/13 vaccination seasons. Nearly all had been vaccinated the previous year although the time interval between the two vaccine doses differed. One subgroup was re-vaccinated in 2012/13 within 6-9 months of their 2011/12 vaccination, the other received the two doses of vaccine in the typical ~12 month interval. Unexpectedly the sub-cohort with early revaccination exhibited significantly increased response rates and antibody titers to TIV compared to their normally re-vaccinated aged counter parts. Microarray analyses of gene expression in whole blood RNA taken at the day of the 2012/13 re-vaccination revealed statistically significant differences in expression of 754 genes between the individuals with early re-vaccination compared to subjects vaccinated in a normal 12 month interval. These observations suggest that TIV has long-lasting effects on the immune system affecting B cell responses as well as the transcriptome of peripheral blood mononuclear cells and this residual effect may augment vaccination response in patients where the effect of the previous vaccination has not yet diminished.
Collection C7: Immunologic Signature
      VAX: HIPC Vaccine Response
Source publication Pubmed 26637961   Authors: Kannan S,Kossenkov A,Kurupati RK,Xiang JZ,Doyle SA,Schmader KE,Schowe L,Ertl HC
Exact source Suppl Table, see also Fig 3
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Organism Homo sapiens
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