Human Gene Set: KATSANOU_ELAVL1_TARGETS_DN

For the Mouse gene set with the same name, see KATSANOU_ELAVL1_TARGETS_DN

Standard name KATSANOU_ELAVL1_TARGETS_DN
Systematic name M2387
Brief description Genes down-regulated in MEF cells (embryonic fibroblast) with ELAVL1 [GeneID=1994] knocked out.
Full description or abstract HuR is an RNA-binding protein implicated in a diverse array of pathophysiological processes due to its effects on the posttranscriptional regulation of AU- and U-rich mRNAs. Here we reveal HuR's requirement in embryonic development through its genetic ablation. Obligatory HuR-null embryos exhibited a stage retardation phenotype and failed to survive beyond midgestation. By means of conditional transgenesis, we restricted HuR's mutation in either embryonic or endothelial compartments to demonstrate that embryonic lethality is consequent to defects in extraembryonic placenta. HuR's absence impaired the invagination of allantoic capillaries into the chorionic trophoblast layer and the differentiation of syncytiotrophoblast cells that control the morphogenesis and vascularization of the placental labyrinth and fetal support. HuR-null embryos rescued from these placental defects proceeded to subsequent developmental stages but displayed defects in skeletal ossification, fusions in limb elements, and asplenia. By coupling gene expression measurements, data meta-analysis, and HuR-RNA association assays, we identified transcription and growth factor mRNAs controlled by HuR, primarily at the posttranscriptional level, to guide morphogenesis, specification, and patterning. Collectively, our data demonstrate the dominant role of HuR in organizing gene expression programs guiding placental labyrinth morphogenesis, skeletal specification patterns, and splenic ontogeny.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 19307312   Authors: Katsanou V,Milatos S,Yiakouvaki A,Sgantzis N,Kotsoni A,Alexiou M,Harokopos V,Aidinis V,Hemberger M,Kontoyiannis DL
Exact source Table 3a
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Source species Mus musculus
Contributed by Arthur Liberzon (MSigDB Team)
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identifier namespace		 Mouse_NCBI_Gene_ID
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Version history 3.1: First introduced

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