Gene Set: KAYO_AGING_MUSCLE_UP

Standard name KAYO_AGING_MUSCLE_UP
Systematic name M16050
Brief description Upregulated in the vastus lateralis muscle of aged vs young adult rhesus monkeys
Full description or abstract In laboratory rodents, caloric restriction (CR) retards several age-dependent physiological and biochemical changes in skeletal muscle, including increased steady-state levels of oxidative damage to lipids, DNA, and proteins. We have previously used high-density oligonucleotide arrays to show that CR can prevent or delay most of the major age-related transcriptional alterations in the gastrocnemius muscle of C57BL/6 mice. Here we report the effects of aging and adult-onset CR on the gene expression profile of 7,070 genes in the vastus lateralis muscle from rhesus monkeys. Gene expression analysis of aged rhesus monkeys (mean age of 26 years) was compared with that of young animals (mean age of 8 years). Aging resulted in a selective up-regulation of transcripts involved in inflammation and oxidative stress, and a down-regulation of genes involved in mitochondrial electron transport and oxidative phosphorylation. Middle-aged monkeys (mean age of 20 years) subjected to CR since early adulthood (mean age of 11 years) were studied to determine the gene expression profile induced by CR. CR resulted in an up-regulation of cytoskeletal protein-encoding genes, and also a decrease in the expression of genes involved in mitochondrial bioenergetics. Surprisingly, we did not observe any evidence for an inhibitory effect of adult-onset CR on age-related changes in gene expression. These results indicate that the induction of an oxidative stress-induced transcriptional response may be a common feature of aging in skeletal muscle of rodents and primates, but the extent to which CR modifies these responses may be species-specific.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 11309484   Authors: Kayo T,Allison DB,Weindruch R,Prolla TA
Exact source Table 6S
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Organism Macaca mulatta
Contributed by John Newman (University of Washington)
Source platform AFFY_HuGene
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Version history 3.0: Renamed from AGED_RHESUS_UP

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