Gene Set: KEGG_HOMOLOGOUS_RECOMBINATION

Standard name KEGG_HOMOLOGOUS_RECOMBINATION
Systematic name M11675
Brief description Homologous recombination
Full description or abstract Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Collection C2: curated gene sets
      CP: canonical pathways
            CP:KEGG: KEGG gene sets
Source publication  
Exact source hsa03440
Related gene sets  
External links http://www.genome.jp/kegg/pathway/hsa/hsa03440.html
Filtered by similarity
Organism Homo sapiens
Contributed by KEGG (Kyoto Encyclopedia of Genes and Genomes)
Source platform Human_NCBI_Gene_ID
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Compendia expression profiles GTEx compendium
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Global Cancer Map (Broad Institute)
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