Gene Set: KEGG_LEISHMANIA_INFECTION

Standard name KEGG_LEISHMANIA_INFECTION
Systematic name M3126
Brief description Leishmania infection
Full description or abstract Leishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and proliferate intracellularly by deactivating the macrophage. Successful infection of Leishmania is achieved by alteration of signaling events in the host cell, leading to enhanced production of the autoinhibitory molecules like TGF-beta and decreased induction of cytokines such as IL12 for protective immunity. Nitric oxide production is also inhibited. In addition, defective expression of major histocompatibility complex (MHC) genes silences subsequent T cell activation mediated by macrophages, resulting in abnormal immune responses.
Collection C2: curated gene sets
      CP: canonical pathways
            CP:KEGG: KEGG gene sets
Source publication  
Exact source hsa05140
Related gene sets  
External links http://www.genome.jp/kegg/pathway/hsa/hsa05140.html
Filtered by similarity
Organism Homo sapiens
Contributed by KEGG (Kyoto Encyclopedia of Genes and Genomes)
Source platform Human_NCBI_Gene_ID
Dataset references  
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Compendia expression profiles GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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