Gene Set: KEGG_LYSOSOME

Standard name KEGG_LYSOSOME
Systematic name M11266
Brief description Lysosome
Full description or abstract Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Collection C2: curated gene sets
      CP: Canonical pathways
            CP:KEGG: KEGG gene sets
Source publication  
Exact source hsa04142
Related gene sets  
External links http://www.genome.jp/kegg/pathway/hsa/hsa04142.html
Organism Homo sapiens
Contributed by KEGG (Kyoto Encyclopedia of Genes and Genomes)
Source platform EntrezGeneIds
Dataset references  
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Compendia expression profiles GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 121 genes
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Version history  

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