Human Gene Set: KEGG_NON_HOMOLOGOUS_END_JOINING


Standard name KEGG_NON_HOMOLOGOUS_END_JOINING
Systematic name M7857
Brief description Non-homologous end-joining
Full description or abstract Nonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation. NHEJ involves binding of the KU heterodimer to double-stranded DNA ends, recruitment of DNA-PKcs (MRX complex in yeast), processing of ends, and recruitment of the DNA ligase IV (LIG4)-XRCC4 complex, which brings about ligation. A recent study shows that bacteria accomplish NHEJ using just two proteins (Ku and DNA ligase), whereas eukaryotes require many factors. NHEJ repairs DSBs at all stages of the cell cycle, bringing about the ligation of two DNA DSBs without the need for sequence homology, and so is error-prone.
Collection C2: Curated
      CP: Canonical Pathways
            CP:KEGG: KEGG Pathways
Source publication  
Exact source hsa03450
Related gene sets  
External links http://www.genome.jp/kegg/pathway/hsa/hsa03450.html
Filtered by similarity ?
Source species Homo sapiens
Contributed by KEGG (Kyoto Encyclopedia of Genes and Genomes)
Source platform or
identifier namespace		 Human_NCBI_Gene_ID
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 13 genes
Gene families ? Categorize these 13 genes by gene family
Show members (show 14 source identifiers mapped to 13 genes)
Version history  

See MSigDB license terms here. Please note that certain gene sets have special access terms.