Human Gene Set: KEGG_NON_HOMOLOGOUS_END_JOINING
Standard name
KEGG_NON_HOMOLOGOUS_END_JOINING
Systematic name
M7857
Brief description
Non-homologous end-joining
Full description or abstract
Nonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation. NHEJ involves binding of the KU heterodimer to double-stranded DNA ends, recruitment of DNA-PKcs (MRX complex in yeast), processing of ends, and recruitment of the DNA ligase IV (LIG4)-XRCC4 complex, which brings about ligation. A recent study shows that bacteria accomplish NHEJ using just two proteins (Ku and DNA ligase), whereas eukaryotes require many factors. NHEJ repairs DSBs at all stages of the cell cycle, bringing about the ligation of two DNA DSBs without the need for sequence homology, and so is error-prone.
Collection
C2: Curated CP: Canonical Pathways CP:KEGG: KEGG Pathways
Source publication
Exact source
hsa03450
Related gene sets
External links
http://www.genome.jp/kegg/pathway/hsa/hsa03450.html
Filtered by similarity ?
Source species
Homo sapiens
Contributed by
KEGG (Kyoto Encyclopedia of Genes and Genomes)
Source platform or identifier namespace
Human_NCBI_Gene_ID
Dataset references
Download gene set
format: grp | gmt | xml | json | TSV metadata
Compute overlaps ?
(show collections to investigate for overlap with this gene set)
Compendia expression profiles ?
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query
Further investigate
these 13 genes
Gene families ?
Categorize these
13 genes by gene family
Show members
(show 14 source identifiers mapped to 13 genes)
Source Id
NCBI (Entrez) Gene Id
Gene Symbol
Gene Description
10111
10111
RAD50
RAD50 double strand break repair protein [So...
1791
1791
DNTT
DNA nucleotidylexotransferase [Source:HGNC S...
2237
2237
FEN1
flap structure-specific endonuclease 1 [Sour...
2547
2547
XRCC6
X-ray repair cross complementing 6 [Source:H...
27343
27343
POLL
DNA polymerase lambda [Source:HGNC Symbol;Ac...
27434
27434
POLM
DNA polymerase mu [Source:HGNC Symbol;Acc:HG...
3981
3981
LIG4
DNA ligase 4 [Source:HGNC Symbol;Acc:HGNC:6601]
4361
4361
MRE11
MRE11 homolog, double strand break repair nu...
5591
5591
PRKDC
protein kinase, DNA-activated, catalytic sub...
64421
64421
DCLRE1C
DNA cross-link repair 1C [Source:HGNC Symbol...
731751
7518
7518
XRCC4
X-ray repair cross complementing 4 [Source:H...
7520
7520
XRCC5
X-ray repair cross complementing 5 [Source:H...
79840
79840
NHEJ1
non-homologous end joining factor 1 [Source:...
Version history
See MSigDB license terms here . Please note that certain gene sets
have special access terms.