Human Gene Set: KIM_HYPOXIA

Standard name KIM_HYPOXIA
Systematic name M1496
Brief description Genes up-regulated in normal fibroblasts under hypoxia conditions.
Full description or abstract Little is known about the detail of hypoxia-responsive gene expression patterns in advanced age, even though aging is thought to be partially associated with a decreased response to hypoxia. In the present study, we identified several hypoxia-inducible genes and investigated the effect of aging on hypoxic gene expression profiles using cDNA microarray analysis of young/old human diploid fibroblasts. Of 7458 genes in the microarray, we found that genes involved in angiogenesis, defense against oxidative stress, and transcription regulation are severely impaired in senescent cell, which is consistent with the fact that aged cells have attenuated responses to various stimuli.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 14499499   Authors: Kim H,Lee DK,Choi JW,Kim JS,Park SC,Youn HD
Exact source Table 3
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Source species Homo sapiens
Contributed by John Newman (University of Washington)
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Version history 3.1: First introduced

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