Systematic name M1177
Brief description Genes down-regulated in colorectal carcinoma samples positive for MSI (microsatellite instability) compared to the MSI negative ones.
Full description or abstract Mutation or epigenetic silencing of mismatch repair genes, such as MLH1 and MSH2, results in microsatellite instability (MSI) in the genome of a subset of colorectal carcinomas (CRCs). However, little is yet known of genes that directly contribute to tumor formation in such cancers. To characterize MSI-dependent changes in gene expression, we have now compared transcriptomes between fresh CRC specimens positive or negative for MSI (n=10 for each) with the use of high-density oligonucleotide microarrays harboring >44,000 probe sets. Correspondence analysis of the expression patterns of isolated MSI-associated genes revealed that the transcriptome of MSI+ CRCs is clearly distinct from that of MSI- CRCs. Such MSI-associated genes included that for AXIN2, an important component of the WNT signaling pathway. AXIN2 was silenced, apparently as a result of extensive methylation of its promoter region, specifically in MSI+ CRC specimens. Forced expression of AXIN2, either by treatment with 5'-azacytidine or by transfection with AXIN2 cDNA, resulted in rapid cell death in an MSI+ CRC cell line. These data indicate that epigenetic silencing of AXIN2 is specifically associated with carcinogenesis in MSI+ CRCs.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 16247484   Authors: Koinuma K,Yamashita Y,Liu W,Hatanaka H,Kurashina K,Wada T,Takada S,Kaneda R,Choi YL,Fujiwara SI,Miyakura Y,Nagai H,Mano H
Exact source Table 1S
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(show 12 gene sets from the same authors)
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Source species Homo sapiens
Contributed by Arthur Liberzon (MSigDB Team)
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Version history 5.0: Renamed from KOINUMA_COLON_CANCER_MSI_UP

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