Human Gene Set: LEF1_UP.V1_DN

Standard name LEF1_UP.V1_DN
Systematic name M2903
Brief description Genes down-regulated in DLD1 cells (colon carcinoma) over-expressing LEF1 [GeneID=51176].
Full description or abstract We treated DLD1 cells with an adenoviral LEF-1 expression construct, which induced EMT within 48 hours. RNA was then extracted from these cells along with untreated DLD1 cells, then subjected to microarray analysis.
Collection C6: Oncogenic Signature
Source publication Authors: Medici DD,Hay ED,Olsen BR
Exact source DLD1+LEF-1 vs DLD1; bottom 150 genes
Related gene sets (show 1 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Homo sapiens
Contributed by Pablo Tamayo (Broad Institute)
Source platform or
identifier namespace
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 187 genes
Gene families ? Categorize these 187 genes by gene family
Show members (show 200 source identifiers mapped to 187 genes)
Version history  

See MSigDB license terms here. Please note that certain gene sets have special access terms.