Gene Set: LIANG_SILENCED_BY_METHYLATION_UP

Standard name LIANG_SILENCED_BY_METHYLATION_UP
Systematic name M14553
Brief description Genes up-regulated in LD419 cells (fibroblast) after treatment with decitabine (5-aza-2'-deoxycytidine) [PubChem=451668].
Full description or abstract Hypermethylation of the promoters of cancer-related genes is often associated with their inactivation during tumorigenesis. Several preclinical and clinical trials have been developed to use DNA methylation inhibitors, such as 5-aza-2'-deoxycytidine (5-Aza-CdR) in attempts to reactivate silenced genes in human cancers. We used high-density oligonucleotide gene expression microarrays to examine the effects of 5-Aza-CdR treatment on human fibroblast cells (LD419) and a human bladder tumor cell line (T24). Data obtained 8 days after recovery from 5-Aza-CdR treatment showed that more genes were induced in tumorigenic cells (61 genes induced; >or=4-fold) than nontumorigenic cells (34 genes induced; >or= 4-fold). Approximately 60% of induced genes did not have CpG islands within their 5' regions, suggesting that some genes activated by 5-Aza-CdR may not result from the direct inhibition of promoter methylation. Interestingly, a high percentage of genes activated in both cell types belonged to the IFN signaling pathway, confirming data from other tumor cell types.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 11861364   Authors: Liang G,Gonzales FA,Jones PA,Orntoft TF,Thykjaer T
Exact source Table 1
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Organism Homo sapiens
Contributed by John Newman (University of Washington)
Source platform AFFY_HuGene
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Version history 3.0: Renamed from DAC_FIBRO_UP

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